Examples

  • Mesalazine (Mesasal, Pentasa, Salofalk, Pentasa, Mezavant)
  • Sulfasalazine (Salazopyrin)

Uses

Mechanism of action

Exact mechanism poorly understood but has anti-inflammatory effects on the bowel wall

Clearance

Hepatic and GI Tract

Drug information

Sulfasalazine

Dosage
500mg
Frequency
tds, qid
Administration
oral
Half-Life
7.6hrs
Cost
$50 for 200x500mg tablets

Side effects

Contraindications

Cautions

  • G6PD deficiency—increases risk of haemolysis (Sulfasalazine)
  • Asthma or severe allergy - may be exacerbated (Sulfasalazine)
  • Renal Impairment - use with caution
  • Severe Chronic Liver Disease - use with caution
  • Surgery - continue throughout perioperative period

Drug Interactions

Pregnancy

Safe. Give Folic Acid supplement

Breastfeeding

Safe

Monitoring

Notes

See also

Australian Medicines Handbook - Mesalazine
Australian Medicines Handbook - Sulfasalazine
Epocrates - Sulfasalazine
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