Examples

Trade Names (Finasta, Finnacar, Proscar)

Uses

  • Benign Prostatic Hyperplasia
  • Androgenic alopecia

Mechanism of action

5‑alpha-reductase inhibitors prevent the conversion of testosterone to dihydrotestosterone which potently promotes growth of the prostate and male sexual characteristics such as male pattern baldness

Clearance

Hepatic

Drug information

Finasteride

Dosage forms
5mg
Frequency
once daily
Administration
oral
Half-Life
6 hours

Side effects

  • Impotence
  • Decreased libido

Contraindications

None

Cautions

None

Drug Interactions

Pregnancy

Not indicated in females

Breastfeeding

Not indicated in females

Monitoring

Prostate Specific Antigen at baseline then every 6 months

Notes

  • Pregnant women should not handle capsules without gloves
  • It can take up to 6 months fro symptoms to improve

See also

Australian Medicines Handbook - Finasteride
Epocrates - Finasteride