Examples

  • Ondansetron (Zofrana, Zilfojim, Onsetrona)

Uses

Nausea and vomiting including:

Mechanism of action

Blocks Peripheral and central 5HT3 receptors

Clearance

Hepatic

Drug information (by drug)

Ondansetron

Dosage
4,8mg (tablet); 2mg/mL, 2,4mL
Frequency
single dose, once daily, bd
Administration
oral, IV, IM
Half-Life
4.6-5.7hrs
Cost
$33 for 10x8mg tablet

Side effects

Contraindications

Cautions

  • Elderly (>75) - reduce dose if IV
  • Prolonged QT interval or risk factors -use with caution
  • Children - seek specialist advice

Drug Interactions

Pregnancy

Use after 1st trimester if other antiemetics are inadequate

Breastfeeding

No data. 1-2 doses should not cause harm.

Monitoring

Notes

See also

Australian Medicines Handbook - Ondasetron
Epocrates - Ondansetron
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