Examples

Aciclovir
Zovirax

Uses

Mechanism of action

Is a Guanine analogue which is phosphorylated in viral cells and inhibits viral DNA polymerase

Clearance

Renal

Drug information

Aciclovir

Dosage
200,400,800mg (tablet), 25mg/mL, 10,20mL (injection)
Frequency
bd, tds
Administration
oral, iv, topical
Half-Life
2.5-3.3hrs
Cost (if possible)
$143 for 120x800mg tablets

Side effects


Contraindications

Cautions

Pregnancy

Safe

Breastfeeding

Safe

Monitoring

Creatinine

Notes

See also

Australian Medicines Handbook - Aciclovir
Epocrates - Acyclovir
nausea, vomiting, diarrhoea, hallucinations (high dose), headache, encephalopathy (reported in 1% patients with IV use), injection site reactions