Uses

Mechanism of action

Reverses proliferation of the epidermis and reduces the increase in keratinisation seen in hyperkeratotic disorders.

Clearance

Renal/ Hepatic

Drug information

Acitretin

Dosage
10, 25mg
Frequency
once daily
Administration
oral
Half-Life
49hrs
Cost (if possible)
$285 for 100x25mg tablets

Side effects

Contraindications

Cautions

  • Laser eye surgery - separate surgery and treatment by 6 months as drug may cause dry eye
  • Diabetes Mellitus - may alter glucose tolerance
  • Elderly - arthralgias more common
  • Children - risk of epiphyseal closure, seek expert advice
  • Women - advise contraception

Drug Interactions

  • Tetracyclines - may increase risk of benign intracranial hypertension

Pregnancy

Contraindicated. Teratogenic.

Breastfeeding

Contraindicated

Monitoring

Notes

See also

Australian Medicines Handbook - Acitretin
Epocrates - Acitretin
Reverses the epidermal proliferation and increased keratinisation seen in hyperkeratotic disorders.